0
  • DE
  • EN
  • FR
  • International Database and Gallery of Structures

Advertisement

PEDOT:PSS based electrospun nanofibres used as trigger for fibroblasts differentiation

Author(s): ORCID



ORCID

ORCID
Medium: journal article
Language(s): English
Published in: Smart Materials and Structures, , n. 1, v. 33
Page(s): 015009
DOI: 10.1088/1361-665x/ad10bf
Abstract:

Electrospun nanofibres based on poly(styrene sulfonate) doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS) were fabricated using a straightforward procedure which combines electrospinning, sputtering deposition and electrochemical synthesis. In general, electrospun fibre meshes based on conducting polymers are prepared by mixing the conducting polymer with a carrier polymer or chemically coverage of the fibres. In contrast, freestanding nylon 6/6 nanofibre webs were prepared through electrospinning and were coated by sputtering with gold in order to make them conductive. Further, a PEDOT:PSS layer was electrochemically deposited onto the metalized nanofibre meshes and the synthesis parameters were chosen in such a way to preserve the high active area of the fibres. The prepared material was morphologically characterized and the formation of PEDOT:PSS was also demonstrated. The PEDOT:PSS coated nanofibres revealed remarkable electrical properties (sheet resistance of about 3.5 Ω cm−2), similar to those of metalized nanofibres (sheet resistance around 3 Ω cm2). The in vitro studies using L929 fibroblast mouse cells showed that the bioactive material has no cytotoxic effect and allows proliferation. Moreover, after 72 h of incubation, the fibroblasts shrunk their nuclei and spread suggesting that a differentiation in myofibroblast occurs without application of any kind of external stimuli. These results will be helpful for developing efficient materials for wound healing applications that work without energy consumption.

Structurae cannot make the full text of this publication available at this time. The full text can be accessed through the publisher via the DOI: 10.1088/1361-665x/ad10bf.
  • About this
    data sheet
  • Reference-ID
    10748409
  • Published on:
    14/01/2024
  • Last updated on:
    14/01/2024
 
Structurae cooperates with
International Association for Bridge and Structural Engineering (IABSE)
e-mosty Magazine
e-BrIM Magazine