0
  • DE
  • EN
  • FR
  • Base de données et galerie internationale d'ouvrages d'art et du génie civil

Publicité

PEDOT:PSS based electrospun nanofibres used as trigger for fibroblasts differentiation

Auteur(s): ORCID



ORCID

ORCID
Médium: article de revue
Langue(s): anglais
Publié dans: Smart Materials and Structures, , n. 1, v. 33
Page(s): 015009
DOI: 10.1088/1361-665x/ad10bf
Abstrait:

Electrospun nanofibres based on poly(styrene sulfonate) doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS) were fabricated using a straightforward procedure which combines electrospinning, sputtering deposition and electrochemical synthesis. In general, electrospun fibre meshes based on conducting polymers are prepared by mixing the conducting polymer with a carrier polymer or chemically coverage of the fibres. In contrast, freestanding nylon 6/6 nanofibre webs were prepared through electrospinning and were coated by sputtering with gold in order to make them conductive. Further, a PEDOT:PSS layer was electrochemically deposited onto the metalized nanofibre meshes and the synthesis parameters were chosen in such a way to preserve the high active area of the fibres. The prepared material was morphologically characterized and the formation of PEDOT:PSS was also demonstrated. The PEDOT:PSS coated nanofibres revealed remarkable electrical properties (sheet resistance of about 3.5 Ω cm−2), similar to those of metalized nanofibres (sheet resistance around 3 Ω cm2). The in vitro studies using L929 fibroblast mouse cells showed that the bioactive material has no cytotoxic effect and allows proliferation. Moreover, after 72 h of incubation, the fibroblasts shrunk their nuclei and spread suggesting that a differentiation in myofibroblast occurs without application of any kind of external stimuli. These results will be helpful for developing efficient materials for wound healing applications that work without energy consumption.

Structurae ne peut pas vous offrir cette publication en texte intégral pour l'instant. Le texte intégral est accessible chez l'éditeur. DOI: 10.1088/1361-665x/ad10bf.
  • Informations
    sur cette fiche
  • Reference-ID
    10748409
  • Publié(e) le:
    14.01.2024
  • Modifié(e) le:
    14.01.2024
 
Structurae coopère avec
International Association for Bridge and Structural Engineering (IABSE)
e-mosty Magazine
e-BrIM Magazine